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Uhlén M, et al. (2015) Proteomics. Tissue-based map of the human proteome. Science 347(6220):1260419. doi:10.1126/science.1260419

Title Proteomics. Tissue-based map of the human proteome.
Abstract Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
Authors Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F
Author Affiliation Science for Life Laboratory, KTH-Royal Institute of Technology, SE-171 21 Stockholm, Sweden. Department of Proteomics, KTH-Royal Institute of Technology, SE-106 91 Stockholm, Sweden. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 Hørsholm, Denmark.
Journal Science (ISSN:1095-9203)
Publication Date Jan 23 2015
MeSH Keywords Alternative Splicing, Cell Line, Databases, Protein, Female, Genes, Genetic Code, Humans, Internet, Male, Membrane Proteins/genetics/metabolism, Mitochondrial Proteins/genetics/metabolism, Neoplasms/genetics/metabolism, Protein Array Analysis, Protein Isoforms/genetics/metabolism, Proteome/genetics/metabolism, Tissue Distribution, Transcription, Genetic
Link PubMed
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