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From Human Salivary Proteome Wiki
Alpha-amylase 1A [Homo sapiens]
Names and Origin
Protein names
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Official name:
Alpha-amylase 1A
Alternative name(s): 1,4-alpha-D-glucan glucanohydrolase 1, Salivary alpha-amylase
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Genes
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Organism
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Homo sapiens
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Taxonomy
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Eukaryota > Opisthokonta > Metazoa > Eumetazoa > Bilateria > Deuterostomia > Chordata > Craniata > Vertebrata > Gnathostomata > Teleostomi > Euteleostomi > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda > Amniota > Mammalia > Theria > Eutheria > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea > Hominidae > Homininae > Homo
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Sequence Attributes
Features
Glycans
There are currently no glycans associated with the protein.
Expression
Abundance and localization of gene products based on both RNA and immunohistochemistry data from the Human Protein Atlas. Click on the tissue names to view primary data.
Proteomics
loading table... |
3D Structures
Entry | Method | Resolution | Chain | Positions | Viewer |
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1C8Q | X-ray | 2.30 A | A | 16-511 | Open | 1JXJ | X-ray | 1.99 A | A | 16-511 | Open | 1JXK | X-ray | 1.90 A | A | 16-511 | Open | 1MFU | X-ray | 2.00 A | A | 17-511 | Open | 1MFV | X-ray | 2.00 A | A | 17-511 | Open | 1NM9 | X-ray | 2.10 A | A | 16-511 | Open | 1Q4N | X-ray | 2.07 A | X | 16-511 | Open | 1SMD | X-ray | 1.60 A | A | 17-511 | Open | 1XV8 | X-ray | 3.00 A | A/B | 16-511 | Open | 1Z32 | X-ray | 1.60 A | X | 16-511 | Open | 3BLK | X-ray | 2.00 A | A | 16-511 | Open | 3BLP | X-ray | 1.60 A | X | 16-511 | Open | 3DHP | X-ray | 1.50 A | A | 16-511 | Open |
Cross References
Keywords
3D-structure, Calcium, Carbohydrate metabolism, Chloride, Disulfide bond, Glycoprotein, Glycosidase, Hydrolase, Metal-binding, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal |
References
1. | Nishide T, et al. (1986) Primary structure of human salivary alpha-amylase gene. Gene 41(2-3):299-304 [PubMed:2423416] | 2. | Nishide T, et al. (1984) Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]. Gene 28(2):263-70 [PubMed:6610603] | 3. | Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36(1):40-5 [PubMed:14702039] | 4. | Gregory SG, et al. (2006) The DNA sequence and biological annotation of human chromosome 1. Nature 441(7091):315-21 [PubMed:16710414] | 5. | Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7 [PubMed:15489334] | 6. | Gumucio DL, et al. (1988) Concerted evolution of human amylase genes. Mol. Cell. Biol. 8(3):1197-205 [PubMed:2452973] | 7. | Handy DE, et al. (1987) Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. Mol. Biol. Med. 4(3):145-55 [PubMed:2442579] | 8. | Bank RA, et al. (1991) Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase. Electrophoresis 12(1):74-9 [PubMed:1710976] | 9. | Ramachandran P, et al. (2006) Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J. Proteome Res. 5(6):1493-503 [PubMed:16740002] | 10. | Ramasubbu N, et al. (1996) Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity. Acta Crystallogr. D Biol. Crystallogr. 52(Pt 3):435-46 [PubMed:15299664] | 11. | Ramasubbu N, et al. (2003) Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase. J. Mol. Biol. 325(5):1061-76 [PubMed:12527308] | 12. | Schwenk JM, et al. (2017) The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays. J. Proteome Res. 16(12):4299-4310. doi:10.1021/acs.jproteome.7b00467 [PubMed:28938075] |
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Entry Information
Entry name
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AMY1A_HUMAN
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Accession
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Primary accession number: P0DUB6
Secondary accession number(s): A6NJS5, A8K8H6, P04745, Q13763, Q5T083
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Dataset
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Swiss-Prot
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Created on
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2020-12-02
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Last modified on
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2023-09-13
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Link
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UniProt
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HSPW Version 1.5.3. This page was last modified on 16 September 2023, at 07:54.This page has been accessed 1,736 times.
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