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Alpha-amylase 1A [Homo sapiens]

Names and Origin

Protein names

Official name:

Alpha-amylase 1A

Alternative name(s):

1,4-alpha-D-glucan glucanohydrolase 1, Salivary alpha-amylase
1.AMY1A [EntrezGene:276]
2.AMY1B [EntrezGene:277]
3.AMY1C [EntrezGene:278]

Homo sapiens

Taxonomy Eukaryota > Opisthokonta > Metazoa > Eumetazoa > Bilateria > Deuterostomia > Chordata > Craniata > Vertebrata > Gnathostomata > Teleostomi > Euteleostomi > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda > Amniota > Mammalia > Theria > Eutheria > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea > Hominidae > Homininae > Homo

Sequence Attributes

Identifier Name Aliases Sequence length Molecular mass Sequence
P0DUB6-1 Canonical sequence 511511 57767.557,767.5 HSPW:PD0564E/1




There are currently no glycans associated with the protein.


Abundance and localization of gene products based on both RNA and immunohistochemistry data from the Human Protein Atlas. Click on the tissue names to view primary data.


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3D Structures

1C8QX-ray2.30 AA16-511Open
1JXJX-ray1.99 AA16-511Open
1JXKX-ray1.90 AA16-511Open
1MFUX-ray2.00 AA17-511Open
1MFVX-ray2.00 AA17-511Open
1NM9X-ray2.10 AA16-511Open
1Q4NX-ray2.07 AX16-511Open
1SMDX-ray1.60 AA17-511Open
1XV8X-ray3.00 AA/B16-511Open
1Z32X-ray1.60 AX16-511Open
3BLKX-ray2.00 AA16-511Open
3BLPX-ray1.60 AX16-511Open
3DHPX-ray1.50 AA16-511Open

Cross References

RefSeq NP_001008219.1; NM_001008218.1; NP_001008220.1; NM_001008219.2; NP_001008222.1; NM_001008221.1; NP_001333709.1; NM_001346780.1; NP_004029.2; NM_004038.3; XP_011539564.1; XM_011541262.1; XP_016856547.1; XM_017001058.1
PDB 1C8Q; 1JXJ; 1JXK; 1MFU; 1MFV; 1NM9; 1Q4N; 1SMD; 1XV8; 1Z32; 3BLK; 3BLP; 3DHP
Ensembl ENST00000370083.9; ENSP00000359100.4; ENSG00000237763.10
GeneCards AMY1A


3D-structure, Calcium, Carbohydrate metabolism, Chloride, Disulfide bond, Glycoprotein, Glycosidase, Hydrolase, Metal-binding, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal


1.Nishide T, et al. (1986) Primary structure of human salivary alpha-amylase gene. Gene 41(2-3):299-304 [PubMed:2423416]
2.Nishide T, et al. (1984) Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]. Gene 28(2):263-70 [PubMed:6610603]
3.Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36(1):40-5 [PubMed:14702039]
4.Gregory SG, et al. (2006) The DNA sequence and biological annotation of human chromosome 1. Nature 441(7091):315-21 [PubMed:16710414]
5.Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7 [PubMed:15489334]
6.Gumucio DL, et al. (1988) Concerted evolution of human amylase genes. Mol. Cell. Biol. 8(3):1197-205 [PubMed:2452973]
7.Handy DE, et al. (1987) Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. Mol. Biol. Med. 4(3):145-55 [PubMed:2442579]
8.Bank RA, et al. (1991) Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase. Electrophoresis 12(1):74-9 [PubMed:1710976]
9.Ramachandran P, et al. (2006) Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J. Proteome Res. 5(6):1493-503 [PubMed:16740002]
10.Ramasubbu N, et al. (1996) Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity. Acta Crystallogr. D Biol. Crystallogr. 52(Pt 3):435-46 [PubMed:15299664]
11.Ramasubbu N, et al. (2003) Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase. J. Mol. Biol. 325(5):1061-76 [PubMed:12527308]
12.Schwenk JM, et al. (2017) The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays. J. Proteome Res. 16(12):4299-4310. doi:10.1021/acs.jproteome.7b00467 [PubMed:28938075]

Entry Information

Entry name AMY1A_HUMAN
Accession Primary accession number: P0DUB6

Secondary accession number(s): A6NJS5, A8K8H6, P04745, Q13763, Q5T083

Dataset Swiss-Prot
Created on 2020-12-02
Last modified on 2023-09-13
Link UniProt
HSPW Version 1.5.3. This page was last modified on 16 September 2023, at 07:54.This page has been accessed 1,736 times.