HSPW:PD0564E Alpha-amylase 1A

From Human Salivary Proteome Wiki

Alpha-amylase 1A [Homo sapiens]

Names and Origin

Protein names

Official name:

Alpha-amylase 1A

Alternative name(s):

1,4-alpha-D-glucan glucanohydrolase 1, Salivary alpha-amylase

Genes

1.	AMY1A [EntrezGene:276]
2.	AMY1B [EntrezGene:277]
3.	AMY1C [EntrezGene:278]

Organism

Homo sapiens

Taxonomy

Eukaryota > Opisthokonta > Metazoa > Eumetazoa > Bilateria > Deuterostomia > Chordata > Craniata > Vertebrata > Gnathostomata > Teleostomi > Euteleostomi > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda > Amniota > Mammalia > Theria > Eutheria > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea > Hominidae > Homininae > Homo

Sequence Attributes

Identifier	Name	Aliases	Sequence length	Molecular mass	Sequence
P0DUB6-1	Canonical sequence		511511	57767.557,767.5	HSPW:PD0564E/1

Comments

Features

Glycans

There are currently no glycans associated with the protein.

Expression

Abundance and localization of gene products based on both RNA and immunohistochemistry data from the Human Protein Atlas. Click on the tissue names to view primary data.

Proteomics

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3D Structures

Entry	Method	Resolution	Chain	Positions	Viewer
1C8Q	X-ray	2.30 A	A	16-511	Open
1JXJ	X-ray	1.99 A	A	16-511	Open
1JXK	X-ray	1.90 A	A	16-511	Open
1MFU	X-ray	2.00 A	A	17-511	Open
1MFV	X-ray	2.00 A	A	17-511	Open
1NM9	X-ray	2.10 A	A	16-511	Open
1Q4N	X-ray	2.07 A	X	16-511	Open
1SMD	X-ray	1.60 A	A	17-511	Open
1XV8	X-ray	3.00 A	A/B	16-511	Open
1Z32	X-ray	1.60 A	X	16-511	Open
3BLK	X-ray	2.00 A	A	16-511	Open
3BLP	X-ray	1.60 A	X	16-511	Open
3DHP	X-ray	1.50 A	A	16-511	Open

Cross References

RefSeq	NP_001008219.1; NM_001008218.1; NP_001008220.1; NM_001008219.2; NP_001008222.1; NM_001008221.1; NP_001333709.1; NM_001346780.1; NP_004029.2; NM_004038.3; XP_011539564.1; XM_011541262.1; XP_016856547.1; XM_017001058.1
PDB	1C8Q; 1JXJ; 1JXK; 1MFU; 1MFV; 1NM9; 1Q4N; 1SMD; 1XV8; 1Z32; 3BLK; 3BLP; 3DHP
Ensembl	ENST00000370083.9; ENSP00000359100.4; ENSG00000237763.10
GeneCards	AMY1A

Keywords

3D-structure, Calcium, Carbohydrate metabolism, Chloride, Disulfide bond, Glycoprotein, Glycosidase, Hydrolase, Metal-binding, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal

References

1.	Nishide T, et al. (1986) Primary structure of human salivary alpha-amylase gene. Gene 41(2-3):299-304 [PubMed:2423416]
2.	Nishide T, et al. (1984) Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]. Gene 28(2):263-70 [PubMed:6610603]
3.	Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36(1):40-5 [PubMed:14702039]
4.	Gregory SG, et al. (2006) The DNA sequence and biological annotation of human chromosome 1. Nature 441(7091):315-21 [PubMed:16710414]
5.	Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7 [PubMed:15489334]
6.	Gumucio DL, et al. (1988) Concerted evolution of human amylase genes. Mol. Cell. Biol. 8(3):1197-205 [PubMed:2452973]
7.	Handy DE, et al. (1987) Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. Mol. Biol. Med. 4(3):145-55 [PubMed:2442579]
8.	Bank RA, et al. (1991) Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase. Electrophoresis 12(1):74-9 [PubMed:1710976]
9.	Ramachandran P, et al. (2006) Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J. Proteome Res. 5(6):1493-503 [PubMed:16740002]
10.	Ramasubbu N, et al. (1996) Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity. Acta Crystallogr. D Biol. Crystallogr. 52(Pt 3):435-46 [PubMed:15299664]
11.	Ramasubbu N, et al. (2003) Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase. J. Mol. Biol. 325(5):1061-76 [PubMed:12527308]
12.	Schwenk JM, et al. (2017) The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays. J. Proteome Res. 16(12):4299-4310. doi:10.1021/acs.jproteome.7b00467 [PubMed:28938075]

Entry Information

Entry name	AMY1A_HUMAN
Accession	Primary accession number: P0DUB6 Secondary accession number(s): A6NJS5, A8K8H6, P04745, Q13763, Q5T083
Dataset	Swiss-Prot
Created on	2020-12-02
Last modified on	2023-02-22
Link	UniProt